Mailsmith, the email client from the makers of BBEdit, is just as powerful and feature-rich as the text editor.
It's a pity Mailsmith supports POP accounts only, and a — adequately empowering — rich-text editor could be a neat addition, too. Mailsmith comes with a world class (plain text) message editor
Mia for Gmail (was Notifier Pro for Gmail) is a desktop Gmail client which sits politely in your menu bar.
E-mail client that is developed from scratch to be a simple, easy-to-use e-mail client with many features, based on the Cocoa framework.
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