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Rocket.Chat is a Web Chat Server, developed in JavaScript.

Yakyak is an open source chat client for Google Hangouts.

An unofficial and privacy-focused Facebook Messenger application.

Use the WhatsApp application on your Mac OS system.

Use the Pushbullet web app without opening your browser.

Manage one or multiple Twitter accounts on your Mac.

Windows

Windows Mac

Zoho Corporation Pvt.

Zoho Mail - Desktop

Free

Brings the comfort of your webmail in your desktop.