Current for Facebook is a Mac app that provides easy access to your Facebook notifications, messages, and buddy list. With Current, conversations open in their own window, allowing you to keep track of important messages from friends and family. You can customize your notifications to minimize distractions, and you can even pop out videos from the page so you can keep watching while doing other things.
Badoo Desktop is a free desktop application that allows you to find out friends
Biba provides a rich visual interface for conference calls.
iMessenger is a Facebook chat application for your Mac.
WhatsDesktop is an open source WhatsApp client for Mac OS.
Simple, stand-alone interface to Twitter.com, one of the web's newest online communities.
Virtual Office Desktop is a comprehensive Unified Communications client app.
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